Table 1.
Plasma | Muscle | Liver | Kidney | ||||||
---|---|---|---|---|---|---|---|---|---|
Parameter | Unit | Fresh water | Brackish water | Fresh water | Brackish water | Fresh water | Brackish water | Fresh water | Brackish water |
Cmax | ug/(g or ml) | 0.91 | 0.76 | 0.62 | 0.51 | 3.87 | 2.70 | 3.39 | 2.99 |
Tmax | h | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 0.5 | 1 | 1 |
t1/2α | h | 3.25 | 1.85 | 0.31 | 1.12 | 0.35 | 2.69 | 0.76 | 2.87 |
t1/2β | h | 71.15 | 56.46 | 44.88 | 36.17 | 23.86 | 15.31 | 150.23 | 132.64 |
t1/2Ka | h | 0.16 | 0.028 | 0.058 | 0.57 | 0.15 | 0.031 | 0.307 | 0.64 |
V1/F | L/kg | 23.57 | 30.15 | 21.53 | 22.22 | 28.38 | 97.33 | 34.30 | 87.17 |
CL/F | L/h/kg | 0.755 | 1.042 | 1.961 | 0.974 | 0.481 | 0.308 | 1.878 | 0.350 |
AUC(0-t) | μg/L⋅h | 17.951 | 14.614 | 8.096 | 6.865 | 34.984 | 44.047 | 10.411 | 38.663 |
AUC(0-∞) | μg/L⋅h | 26.464 | 19.189 | 10.196 | 20.515 | 41.547 | 64.823 | 10.645 | 57.132 |
K10 | 1/h | 0.064 | 0.035 | 0.091 | 0.044 | 0.17 | 0.048 | 0.34 | 0.16 |
K12 | 1/h | 0.235 | 0.212 | 1.574 | 0.474 | 1.469 | 0.113 | 2.034 | 0.754 |
K21 | 1/h | 0.104 | 0.14 | 0.548 | 0.103 | 0.355 | 0.036 | 0.245 | 0.042 |
Ka | 1/h | 4.201 | 25.183 | 11.951 | 1.203 | 4.537 | 22.106 | 2.26 | 1.082 |
Cmax, the peak concentration in plasma; Tmax, the time point of the drug’s maximum plasma concentration; t1/2α, distribution half-life of the drug; t1/2β, elimination half-life of the drug; t1/2Ka, absorption half-life of the drug; V1/F, extensive apparent volume of the central compartment; CL/F, total body clearance of the drug; AUC(0-t), area under the concentration–time curve from 0 h to t; AUC(0-∞), area under the concentration–time curve from 0 h to ∞; K12, K21, first-order rate constants for drug distribution between the central and peripheral compartments; K10, elimination rate constant from the central compartment; Ka, absorption rate constant.