Table 2.
Top ten significantly down-regulated genes in LNCaP cells after EPHB4 siRNA knockdown
| Fold change | Gene symbol | Description | Function |
|---|---|---|---|
| -29.4 | ITGB8 | Integrin beta 8 | Cell-cell and cell-extracellular matrix interactions |
| -10.5 | LOC100287846 | Patched 1 pseudogene | Uncharacterized |
| -10.5 | PROM1 | Prominin 1/CD133 | Transmembrane glycoprotein, stem cell marker |
| -10.3 | EIF4E3 | Eukaryotic translation initiation factor 4E family member 3 | Recruits mRNA to ribsosome |
| -8.8 | GBP3 | Guanylate Binding Protein 3 | Binding of guanidine nucleotides |
| -8.4 | DOCK10 | Dedicator of Cytokinesis 10 | Guanine nucleotide exchange factor |
| -7.9 | C14orf38 | Open reading frame | Uncharacterized |
| -6.9 | TMC7 | Transmembrane Channel-like 7 | Multi-pass membrane protein |
| -6.8 | SASH1 | SAM and SH3 domain Containing 1 | Candidate tumour suppressor in breast cancer |
| -5.8 | FSD2 | Fibronectin type III and SPRY domain containing 2 | Uncharacterized |