Table 1. see also Figure S1 and Tables S2–S4. Gene ontology results for the top 116 genes correlating with AG.

The top 116 genes (Table S2) associated with adult human brain AG were identified as those that consistently occurred among the top 1,000 out of 17,205 genes whose expression correlates with AG in the AHBA and 5 matched BSS brains. DAVID Bioinformatics Resources (v6.7) was used to functionally characterize these genes (Huang da et al., 2009). Top functional terms with a group enrichment score >1.0 are listed, and in general include axons, dendrites, and the regulation of their development (see Table S3 for the full list). Similar results are obtained using other gene ontology tools including GeneMANIA.org and userListEnrichment (Table S4) (Miller et al., 2011; Warde-Farley et al., 2010). A permutation analysis showed that the discovery of the 116 genes is statistically unlikely by chance alone (Figure S1).

Functional Term	Group Enrichment Score
Neuronal projections; dendrites; axons	2.66
Ion channels	2.25
Synapses; dendritic spines	1.57
Regulation of secretion and transport	1.40
Neuronal development; axonogenesis	1.18
Cytoplasmic vesicles	1.18
Neuronal differentiation; neuron projection development	1.11
Regulation of cell development and differentiation	1.04