Table 1.
KEGG functions enriched for genes correlated with AGS
| KEGG function | Hierarchy level | Direction of correlation | q -value |
|---|---|---|---|
| Metabolism | A | Positive | 0 |
| Metabolism of cofactors and vitamins | B | Positive | 0 |
| Amino acid metabolism | B | Positive | 0 |
| Carbohydrate metabolism | B | Positive | 0 |
| Glycan biosynthesis and metabolism | B | Positive | 2.7E-05 |
| Two-component system | C | Positive | 0 |
| Biosynthesis of amino acids | C | Positive | 0 |
| Glycosaminoglycan degradation | C | Positive | 1.50E-06 |
| Pentose and glucuronate interconversions | C | Positive | 1.07E-05 |
| Lipopolysaccharide biosynthesis | C | Positive | 2.21E-05 |
| Histidine metabolism | C | Positive | 2.24E-05 |
| Fructose and mannose metabolism | C | Positive | 2.69E-05 |
| Carbon metabolism | C | Positive | 2.75E-05 |
| Alanine, aspartate and glutamate metabolism | C | Positive | 2.89E-05 |
| Biotin metabolism | C | Positive | 7.68E-05 |
| Membrane transport | B | Negative | 1.0E-05 |
| Drug resistance | B | Negative | 6.9E-03 |
| Peptidoglycan biosynthesis | C | Negative | 9.5E-10 |
| ABC transporters | C | Negative | 2.3E-05 |
| Pyruvate metabolism | C | Negative | 7.3E-05 |
Functions within the BRITE hierarchy were tested for enrichment, using the cumulative hypergeometric test, for genes that were strongly correlated with AGS (Pearson q < 1e-5). This was performed separately for genes that were positively correlated and genes that were negatively correlated. Listed are the most significant results from this analysis.