Table 3.
Frequency distributions of INF-γ polymorphisms among cases and controls
| Polymorphisms | Frequencyn (%) | CHB vs. Control | HBV-LC vs. Control | |||||
|---|---|---|---|---|---|---|---|---|
| LC = 126 | CHB = 129 | Control = 173 | P | OR (95% CI) | P | OR (95% CI) | ||
| +874(T/A) | ||||||||
| Genotypes | ||||||||
| AA | 90 (71.4) | 84 (65.1) | 116 (67.1) | 1Ref | 1Ref | |||
| AT | 32 (25.4) | 36 (27.9) | 47 (27.2) | 0.781 | 1.086 (0.607-1.943) | 0.588 | 0.863 (0.507-1.470) | |
| TT | 4 (3.2) | 9 (7.0) | 10 (5.8) | 0.481 | 1.458 (0.511-4.159) | 0.264 | 0.505 (0.152-1.675) | |
| Allele | ||||||||
| A | 212 (84.1) | 204 (79.1) | 279 (80.6) | 1Ref | 1Ref | |||
| T | 40 (15.9) | 54 (20.9) | 67 (19.4) | 0.480 | 1.176 (0.750-1.844) | 0.250 | 0.775 (0.505-1.196) | |
| Dominant model AT + TT vs AA | 0.617 | 1.148 (0.668-1.974) | 0.389 | 0.801 (0.483-1.328) | ||||
| Recessive model TT vs AA + AT | 0.505 | 1.421 (0.506-3.991) | 0.291 | 0.526 (0.160-1.730) | ||||
| +2109 (A/G) | ||||||||
| Genotypes | ||||||||
| AA | 79 (62.7) | 72 (55.8) | 82 (47.4) | 1Ref | 1Ref | |||
| AG | 40 (32.7) | 43 (33.3) | 68 (39.3) | 0.640 | 0.874 (0.498-1.534) | 0.071 | 0.630 (0.381-1.041) | |
| GG | 7 (5.6) | 14 (10.9) | 23 (13.3) | 0.256 | 0.625 (0.278-1.407) | 0.014 | 0.321 (0.130-0.793) | |
| Allele | ||||||||
| A | 198 (78.6) | 187 (72.5) | 232 (67.6) | 1Ref | 1Ref | |||
| G | 54 (21.4) | 71 (27.5) | 111 (32.4) | 0.232 | 0.785 (0.528-1.167) | 0.003 | 0.565 (0.388-0.825) | |
| Dominant model AG + GG vs AA | 0.392 | 0.799 (0.478-1.336) | 0.013 | 0.551 (0.344-0.883) | ||||
| Recessive model GG vs AA + AG | 0.295 | 0.659 (0.301-1.440) | 0.034 | 0.385 (0.159-0.930) | ||||
LC, liver cirrhosis; CHB, chronic hepatitis; Ref, reference; OR, odds ratio; 95% CI, 95% confidence interval.
P value: after logistic regressive analysis by adjusting for confounding factors (age, gender, alcohol consumption, etc.).