Table 5.
Genotype frequencies in healthy control subjects in this study and from the HapMap project or previous studies
| SNPs | Number | Genotype frequency | P | Allele frequency | P | |||
|---|---|---|---|---|---|---|---|---|
| +874 T/A | AA | AT | TT | A | T | |||
| This study | 173 | 116 (67.1) | 47 (27.2) | 10 (5.8) | 1Ref | 279 (80.6) | 67 (19.4) | 1Ref |
| Korea [20] | 201 | 151 (75.1) | 47 (23.4) | 3 (1.5) | 0.043 | 249 (82.5) | 53 (17.5) | 0.553 |
| Brazil [18] | 202 | 79 (39.1) | 82 (40.6) | 41 (20.3) | 0.000 | 240 (59.4) | 164 (40.6) | 0.000 |
| India [15] | 146 | 52 (35.6) | 77 (52.7) | 17 (11.6) | 0.000 | 181 (62.0) | 111 (38.0) | 0.032 |
| Tunisia [19] | 103 | 33 (32.0) | 47 (45.6) | 23 (22.3) | 0.000 | 113 (54.9) | 93 (45.1) | 0.000 |
| +2109A/G | AA | AG | GG | A | G | |||
| This study | 173 | 112 (64.7) | 52 (30.1) | 9 (5.2) | 1Ref | 232 (67.6) | 111 (32.4) | 1Ref |
| HCB | 45 | 21 (46.7) | 18 (40.0) | 6 (13.3) | 0.040 | 60 (66.7) | 30 (33.3) | 0.008 |
| JPT | 44 | 16 (36.4) | 13 (29.5) | 15 (34.1) | 0.000 | 45 (51.1) | 43 (48.9) | 0.000 |
| CEU | 58 | 23 (39.7) | 31 (53.4) | 4 (6.9) | 0.003 | 77 (66.4) | 39 (33.6) | 0.003 |
| YRI | 59 | 47 (79.7) | 12 (20.3) | 0 (0) | 0.050 | 106 (89.8) | 12 (10.2) | 0.013 |
HCB Han Chinese in Beijing, China, JPT Japanese in Tokyo, Japan, CEU Utah residents with Northern and Western.
European ancestry, YRI Yoruba in Ibadan, Nigeria.