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. 2004 Jun 7;101(25):9309–9314. doi: 10.1073/pnas.0401994101

Fig. 2.

Fig. 2.

Meta-signature of neoplastic transformation. (A) Sixty-seven genes overexpressed in cancer relative to normal tissue counterpart in at least 12 of 39 “cancer vs. normal” signatures. Twelve distinct cancer types were selected for the figure. White boxes signify either not present or not significant. Red boxes signify significant overexpression in cancer relative to normal tissue (Q < 0.10), the shade of red indicating the percentage of cancer samples that had an expression value greater than the 90th percentile of normal samples. (B) The signature significantly predicts “cancer vs. normal” status in 32 of 39 analyses. The two bars above each heat map represent the predicted class (P) and the true class (T): red signifies cancer and blue signifies normal tissue. Fisher's exact test was used to assess the significance of classification. In the heat maps, black signifies data not available, white signifies less than or equal to the normal class mean expression level, and red signifies the degree of overexpression relative to the mean normal class expression level. FL, follicular lymphoma; DLBCL, diffuse large B cell lymphoma; SCLC, small cell lung cancer; SqCLC, squamous cell lung cancer; adeno., adenocarcinoma; Prost., prostate; Glio., glioblastoma; Rh, rhabdomyosarcoma; PNET, primitive neuroectodermal tumor.