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. 2014 Aug 26;16(6):1372–1379. doi: 10.1208/s12248-014-9657-9

Table I.

Polynomial Coefficients, Relative Standard Error, Constant Coefficient, Akaike Information Criterion of the Polynomial Function of the Age-Matched Weight or BMI, and Percent of Simulated Individuals’ Weights or BMI Outside the 90 and 95% Confidence Bands of the CDC and WHO Datasets by Gender and Age Group

Gender Polynomial coefficients AIC CV% % outside
x 5 x 4 x 3 x 2 x 1 x 0 ε a (90% CI, 95% CI)
Body weight
Age range 2–20 years, CDC
Female 2.09 × 10−4 (2.3%) −0.01153 (2.1%) 0.2161 (2.0%) −1.571 (2.1%) 6.616 (1.6%) 4.265 (2.6%) −597.54 ε age < 5 (12)
ε age ≥ 5 (18)
9.9%, 6.2%
Male 0 −1.99 × 10−3 (1.7%) 0.07245 (1.9%) −0.728 (2.5%) 4.720 (1.9%) 5.472 (2.3%) −437.89 ε age < 5 (11)
ε age ≥ 5 (17)
9.6%, 5.5%
Age range 0–2 years, CDC
Female 0 −0.1214 (1.6%) 1.208 (1.2%) −4.571 (0.6%) 9.6 (0.2%) 3.41 (0.1%) −377.3 (12) 9.7%, 6.0%
Male 0 −0.1774 (2.3%) 1.691 (1.5%) −6.052 (0.8%) 11.314 (0.3%) 3.55 (0.2%) −338.25 (11) 9.1%, 5.4%
Age range 0–5 years, WHO
Female 0.034 (9.7%) −0.4883 (8.6%) 2.617 (7.2%) −6.522 (5.7%) 9.885 (2.9%) 3.524 (2.0%) −331.10 (12) 11%, 7%
Male 0.04 (10.7%) −0.5691 (9.5%) 3.041 (8.0%) −7.612 (6.2%) 11.127 (3.4%) 3.758 (2.4%) −294.18 (11) 11%, 7%
Body mass index
Age range 2–20 years, CDC
Female 0 0 −0.0043 (2.0%) 0.1609 (0.2%) −1.3263 (0.3%) 19.169 (0.4%) −961.17 ε 2 ≤ age < 6 (8)
ε 6 ≤ age < 8 (11)
ε 8 ≤ age ≤ 20 (17)
9.5%, 4.6%
Male 0 0 −0.003 (1.9%) 0.1317 (1.4%) −1.2002 (1.7%) 19.332 (0.3%) −1,003.65 ε 2 ≤ age < 6 (6)
ε 6 ≤ age < 8 (10)
ε 8 ≤ age ≤ 20 (14)
9.1%, 5.0%

CV coefficient of variation, CDC Center for Disease Control, WHO World Health Organization, AIC Akaike information criterion, CI confidence interval

aLog-normal distribution assumed