. 2014 Oct 2;16(6):1344–1357. doi: 10.1208/s12248-014-9672-x

Table II.

Calcium Influence at 0, 1.4, 5, and 10 mM on the Extent of Digestion and Its Influence on Un-ionized–Ionized FA Ratios. The Un-ionized–Ionized FFA Ratio Is Calculated by Dividing FFAs Detected at pH 9 with the Sum of FFAs at pH 6.5 and pH 9. The Extent of Digestion Is Based on Calculations from Williams et al. for the Total Amount of FAs Available for Digestion in the LBFs (21)

	Titrated FFA ionized/total FFA released (mmol)				Un-ionized–ionized FFA ratio				Extent of digestion (%)
LBF type	0^a	1.4^b	5^c	10^c	0^a	1.4^d	5^b	10^c	0^d	1.4^b	5^b	10^d
I-LC	0.05/0.79	0.09/0.54	0.19/0.53	0.35/93	14.84	5.00	1.74	1.63	35	25	24	42
II-LC	0.08/1.00	0.12/1.00	0.21/1.01	0.33/0.98	11.50	7.33	3.81	1.97	50–70	50–70	51–71	49–69
IIIA-LC	0.31/1.44	0.36/1.32	0.53/2.41	0.70/1.86	3.65	2.67	3.55	1.66	71–101	65–92	118–169	91–130
I-MC	2.25/3.15	2.30/3.44	2.48/3.68	2.84/4.15	0.40	0.50	0.48	0.46	81	88	94	106
II-MC	1.71/2.91	1.82/3.00	1.84/2.86	2.20/3.11	0.70	0.65	0.55	0.41	94–115	96–118	92–113	100–122
IIIA-MC	1.69/2.45	1.88/2.67	1.87/2.75	2.23/3.18	0.45	0.42	0.47	0.43	83–96	90–105	93–108	107–125
IIIB-MC	0.79/1.32	0.88/1.28	0.93/1.32	1.04/1.38	0.67	0.45	0.42	0.33	84–138	82–133	84–138	88–144
IV	0.01/0.24	0.03/0.10	0.05/0.37	0.06/0.53	23.00	2.33	6.40	7.83	39	16	61	87

Maximum relative standard deviation (RSD) for the parameter (type IV excluded due to low extent of digestion resulting in high RSDs)

^aRSD <50

^bRSD <20

^cRSD <30

^dRSD <10