Table I.
Initial CRs and Their Methods of Obtaining
| Victim drug | CRCYP3A4 | Source | Reference |
|---|---|---|---|
| Alprazolam | 0.75 | Literature | (5) |
| Amitriptyline | 0.25 | Literature | (5) |
| Atorvastatin | 0.68 | Literature | (5) |
| Boceprevir | 0.20 | Calculation (clarithromycin) | (25) |
| Buspirone | 0.99 | Literature | (5) |
| Cerivastatin | 0.18 | Literature | (5) |
| Cyclosporin | 0.80 | Literature | (5) |
| Clarithromycin | 0.35 | Calculation (saquinavir) | (26,27) |
| Colchicine | 0.67 | Calculation (cyclosporin) | (28) |
| Dronedarone | 0.90 | Calculation (erythromycin) | (29) |
| Eplerenone | 0.82 | Calculation (erythromycin) | (30) |
| Felodipine | 0.89 | Literature | (5) |
| Gefitinib | 0.39 | Literature | (5) |
| Imatinib | 0.28 | Literature | (5) |
| Ketoconazole | 0.58 | Calculation (telaprevir) | (31) |
| Lovastatin | 1.00 | Literature | (5) |
| Mefloquine | 0.44 | Literature | (5) |
| Methylprednisolone | 0.77 | Calculation (diltiazem) | (32) |
| Midazolam | 0.92 | Literature | (5) |
| Nifedipine | 0.78 | Literature | (5) |
| Nisoldipine | 0.96 | Literature | (5) |
| Prednisolone | 0.18 | Literature | (5) |
| Quietapine | 0.85 | Literature | (5) |
| Quinidine | 0.43 | Calculation (diltiazem) | (33) |
| Rilpivirine | 0.33 | Calculation (ketoconazole) | (34) |
| Rivaroxaban | 0.28 | Calculation (erythromycin) | (35) |
| Saquinavir | 0.73 | Calculation (clarithromycin) | (26,27) |
| Sildenafil | 0.79 | Calculation (erythromycin) | (36) |
| Simvastatin | 1.00 | Literature | (5) |
| Sirolimus | 0.77 | Calculation (verapamil) | (37) |
| Tadalafil | 0.50 | Calculation (ketoconazole) | (38) |
| Telithromycin | 0.49 | Literature | (5) |
| Ticagrelor | 0.79 | Calculation (diltiazem) | (39) |
| Triazolam | 0.93 | Literature | (5) |
| Zopiclone | 0.44 | Literature | (5) |
| Zolpidem | 0.40 | Literature | (5) |
CR contribution ratio