Table IV.

Final Estimates of CR_CYP3A4 Values for Oral Clearance of 37 Substrates (Including 16 New CYP3A4 Substrates)

Drug	CRCYP3A4	New substrates
		SD	90%	CI
Lovastatin	1.00
Buspirone	0.99
Nisoldipine	0.97
Simvastatin	0.97
Dronedarone	0.95	0.005	0.94	0.96
Triazolam	0.93
Midazolam	0.91
Tacrolimus	0.91	0.028	0.86	0.95
Felodipine	0.87
Ticagrelor	0.87	0.013	0.84	0.89
Quietapine	0.85
Sirolimus	0.84	0.052	0.75	0.92
Eplerenone	0.79	0.064	0.68	0.88
Sildenafil	0.78	0.053	0.68	0.86
Alprazolam	0.75
Nifedipine	0.72
Colchicine	0.71	0.033	0.65	0.76
Atorvastatin	0.68
Cyclosporin	0.68
Methylprednisolone	0.68	0.046	0.59	0.74
Ketoconazole	0.63	0.062	0.51	0.71
Saquinavir	0.58	0.066	0.55	0.77
Tadalafil	0.50	0.080	0.36	0.62
Telithromycin	0.49
Mefloquine	0.44
Zopiclone	0.44
Quinidine	0.43	0.107	0.25	0.61
Zolpidem	0.40
Gefitinib	0.39
Clarithromycin	0.35	0.089	0.21	0.50
Rivaroxaban	0.35	0.101	0.19	0.52
Rilpivirine	0.33	0.096	0.18	0.49
Imatinib	0.28
Amitriptyline	0.25
Boceprevir	0.22	0.077	0.11	0.36
Cerivastatin	0.18
Prednisolone	0.18

CR contribution ratio, SD standard deviation, CI confidence interval