Table V.

Final Estimates of Apparent IR_CYP3A4 Values of 25 Inhibitors (Including Eight New CYP3A4 Inhibitors)

Inhibitor	Inhibitor dosage (mg/day)	IR	New inhibitors
			SD	90% CI
Ritonavir	800	0.99	0.004	0.98	1.00
Ketoconazole	200–400	0.98
Voriconazole	400	0.98
Telaprevir	2,250	0.97	0.012	0.95	0.99
Itraconazole	100–200	0.95
Clarithromycin	500–1,000	0.94
Grapefruit	DS	0.93	0.02	0.89	0.96
Telithromycin	800	0.91
Saquinavir	3,600	0.88
Boceprevir	2,400	0.87	0.026	0.83	0.91
Posaconazole	100–800	0.86	0.012	0.84	0.88
Nefazodone	400	0.85
Erythromycin	1,000–2,000	0.81
Diltiazem	90–270	0.80
Fluconazole	200	0.75
Cyclosporin	100	0.78	0.077	0.64	0.89
Verapamil	240–480	0.71
Grapefruit	RS	0.51	0.10	0.33	0.67
Cimetidine	800–1,200	0.44
Ranitidine	300–600	0.37
Roxithromycine	300	0.35
Ticagrelor	180	0.35	0.096	0.19	0.51
Fluvoxamine	100–2,00	0.30
Azithromycin	250–500	0.11
Gatifloxacine	400	0.08

IR inhibition ratio, SD standard deviation, CI confidence interval, RS regular strength, DS double strength