Fig. 1.

Effects of gastric pH modulators on plasma concentrations of dasatinib in healthy volunteers. A single-oral dose of 100 mg dasatinib was given on each study day either alone (treatment A), after pretreatment with rabeprazole (treatment B), or after pretreatment with rabeprazole followed by betaine HCL given 5 min prior to dasatinib (treatment B). Points represent the mean of ten subjects (error bars indicating the SD) plotted on a logarithmic scale, with the inset graphs plotted on a linear scale