Table II.

Time Course and Potency of Gastric Reacidification Using BHCl in Healthy Subjects with Rabeprazole-Induced Hypochlorhydria

Time course of BHCl	Mean ± SD (min)
Onset (time to pH <3)	12 ± 21
Rebound time to pH >3	69 ± 77
Potency of BHCl
	pH before BHCl	pH after BHCl	ΔpH
Mean ± SD	4.1 ± 0.9	0.74 ± 0.54	3.4 ± 0.9
Range	2.8–5.2	0.50–3.6	0.61–4.7

Gastric pH data at 1-min intervals from treatment C were used to calculate the time course and potency of BHCl. The time course is described by the onset of effect (time to pH <3) and rebound time to pH >3, relative to BHCl administration, while the potency is described by the ΔpH calculated before and after BHCl administration