Table 1. Biologically active genetic elements isolated by SSA.
Gene of origin | Name | Predicted product | Coordinates | Activity |
---|---|---|---|---|
ATM | GSE-A1 | Antisense RNAs | bp 155—403 | Radiosensitization |
GSE-E1 | Antisense RNAs | bp 8231—8423 | Radiosensitization | |
GSEF2 | Antisense RNAs | bp 8402—8772 | Radiosensitization | |
GSEH2 | Antisense RNAs | bp 8550—8912 | Radiosensitization | |
ΔATMC2 | Truncated proteins | aa 2945—3056 | Radiosensitization | |
ΔATM-A1 | Truncated proteins | aa 894—1012 | Radiosensitization | |
ΔATM-D3 | Truncated proteins | aa 1218—1302 | Radiosensitization | |
p53 | 2f | Mutant proteins | E 221 D | ts GR&T |
2c | Mutant proteins | I 232 F | ts GR&T | |
2g | Mutant proteins | D 208 A | ts GR&T | |
2b | Mutant proteins | M 237 V | ts GR&T | |
2d | Mutant proteins | D 57 G V 272 L | ts GR&T | |
2e | Mutant proteins | T 256 A | ts GR&T | |
4c | Mutant proteins | I 254 F E 343 G | LOF mutant |
Radiosensitization, radiosensitization of U2 OS cells; ts GR&T, ts growth repression and transactivation; LOF, loss of function mutant.