Skip to main content
. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Microbiol Spectr. 2015 Jan 29;3(3):MDNA3-0015-2014. doi: 10.1128/microbiolspec.MDNA3-0015-2014

Figure 2. Type IV Secretion System Model.

Figure 2

ParA and ParB recruit the chromosomal DNA to the type IV secretion system. TraI relaxase nicks the DNA at the oriT site and the DNA is unwound possiblibyl by the Yea helicase. The resulting single stranded DNA possibly still bound by TraI is then secreted through the type IV secretion complex into the extracellular mileu in a contact-independent manner. The inner membrane complex is predicted to consist of TraG, TraD and TraC with TraB spanning both the inner and outer membranes to form a channel for the DNA. The transglycosylases AtlA and LtgX create localized breaks in the peptidoglycan to allow the system to assemble. The outer membrane complex consists of TraB, TraK and TraV.