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. 2004 Jun 15;101(25):9387–9392. doi: 10.1073/pnas.0308179101

Fig. 4.

Fig. 4.

TRPC3 expression is limiting to sustained calcium influx and NFAT transactivation in C2C12 myotubes. (Upper) Calcium transients in cells stimulated with 15 mM caffeine and expressing a CMV-TPRC3 construct or a control vector. Each trace represents the mean value of 5–10 cells from one experiment; similar results were obtained in two additional experiments. (Lower) NFAT-dependent reporter gene expression stimulated by caffeine in myocytes expressing a CMV-TPRC3 construct or a control vector. Data are corrected for variations in transfection efficiency by normalization of data to expression of a cotransfected pCMV-LacZ construct. *, P < 0.004.