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. 2015 Mar 24;15:147. doi: 10.1186/s12879-015-0906-z

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© Mossallam et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Liver histological sections form infected unimmunized control mice (A-E) and FSm14/29-immunized mice (F-J). (A) Liver section of infected unimmunized mouse showing Kupffer cells’ hyperplasia (H&E x100). (B) Liver section of an infected mouse showing hydropic degeneration and ballooning of hepatic cells (H&E x400). (C) Liver section of an infected mouse showing lymphocytic infiltration of portal tract with marked dilatation and proliferation of blood vessels (H&E x100). (D) Liver section of an infected mouse showing numerous large size cellular granulomata (H&E x100). (E) Liver section of an infected mouse showing non-degenerated well developed S. mansoni egg trapped within cellular granuloma (MT x400). (F) Liver section of infected FSm14/29-immunized mouse showing decreased number and size of cellular granulomata surrounding degenerated eggs (H&E x100). (G) Liver section of infected FSm14/29-immunized mouse showing lesser degree of cellular swelling and inflammatory infiltration (H&E x400). (H) Liver section of infected FSm14/29-immunized mouse showing regenerative activity represented by hepatocyte binucleation (arrows) (H&E x400). (I & J) Liver sections of infected FSm14/29-immunized mouse showing small well-circumscribed fibrous granulomata with degenerated eggs (MT X400).