Table 5. Multivariatea Cox Regression Analyses for MLKL, ERCC1 and RRM2 Expression in All Patients (n = 80).
| Outcome | OS | ||
|---|---|---|---|
|
| |||
| HR | 95% CI | Pb | |
| Tumor size | 1.032 | 0.789-1.350 | .818 |
| Positive surgical margins | 1.447 | 0.889-2.355 | .138 |
| Higher grade | 1.174 | 0.727-1.894 | .512 |
| Positive lymph nodes | 1.619 | 0.866-3.028 | .132 |
| PNI | 5.947 | 1.693-20.895 | .005 |
| LVI | 1.331 | 0.734-2.412 | .346 |
| MLKL expressionc | 11.4 | 3.4-27.9 | <.001 |
| ERCC1 expression | 4.100 | 1.951-8.615 | <.001 |
| RRM2 expression | 3.314 | 1.589-6.910 | .001 |
Abbreviations: 95% CI, 95% confidence interval; ERCC1, excision repair cross-complementing gene-1; HR, hazards ratio; LVI, lymphovascular invasion; MLKL, mixed lineage kinase domain-like protein; OS, overall survival; PNI, perineural invasion; RRM2, ribonucleotide reductase subunit M2.
a
Multivariate analysis includes all clinically relevant covariates found to have a P value <.2 on univariate analysis.
b
Bold type denotes statistical significance.
c
MLKL score is decreasing from high expression to low expression. ERCC1 and RRM2 expression are increasing from low overall score to high overall score.