FIG. 5.

Major targets regulated by SIRT5. SIRT5 deacetylates, desuccinylates, demalonylates, and/or deglutarylates multiple metabolic enzymes to activate (blue ellipses) or inhibit (green ellipses), either increasing (yellow rounded rectangle with upward red arrow) or decreasing (yellow rounded rectangles with downward red arrow) the levels/activity of particular compound/cellular activity. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars