FIG. 4.

Blocking the IFNAR partially protected the neurons from IFNα toxicity. Neurons were pretreated with saline, an IFNAR blocker (1, 10, or 50 μg), or an IgG1 K isotype control (IFNGR) (1, 10, or 50 μg) and then exposed to IFNα for 48 h. Dendritic length and number of branches were significantly improved in cultures pretreated with IFNAR Ab at all doses before IFNα exposure compared to cultures treated with IFNα alone or an isotype control. However, cultures pretreated with IFNAR Ab were not completely protected and were significantly different than saline-treated cultures (*P<0.05, **P<0.001).