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IFNα induces neurotoxicity in IFNAR KO mouse neuronal cultures. Significant decreases in dendritic length and branching were evident in neurons extracted from IFNAR KO mouse fetuses that were treated with 300 or 900 U of IFNα for 48 h. Neuron cultures pretreated with TCN 201 before IFNα exposure were not significantly different than saline-treated neurons indicating complete protection from IFNα-induced neurotoxicity when both receptors are inhibited (*P<0.05, **P<0.001, ***P<0.0001).
