Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Anti-Mullerian hormone (AMH) binds to AMH receptor (AMHR-II) then signals via Smad 1/5/8. AMH has an inhibitory effect on follicle growth by decreasing the sensitivity of ovarian follicles to FSH thus inhibiting the loss of oocyte pool by slowing down growth followed by atresia. In human luteinized granulosa cells, leptin down-regulates AMHR-II and vitamin D down-regulates AMHR-II and Smad 1/5/8 phosphorylation and nuclear translocation
