Table 2.
Transplantation to pregnancy and pregnancy outcome
| Ref. | Amount transplanted Graft size (cm2) | Recovery of ovarian functiona (in months) E2; FSHb | Pregnancy | Time from transplanta- tion to pregnancy (months) | Live births No. | Sex | Gestational age (weeks) | Birth weight (gram) | Pregnancy complications | Delivery mode |
|---|---|---|---|---|---|---|---|---|---|---|
| [8] | 4,2/1,4 | 5 | SC | 11 | 1 | Girl | 39 | 3,720 | nd | nd |
| [9] | 2,3+ tiny fragments | 8 | IVF | 9 | 1 | Girl | 38 | 3,000 | None | CS |
| [10, 11] | 4,5/ 1 | 3 | SC/SC | 5/33 | 2 | Girl/Girl | 41/39 | 3,130/2,870 | None/nd | nd/nd |
| [12, case 2] | 1,25/3 | 5/5 | IVF/IVF | 19/85 | 2 | Boy/Boy | 37/36 | 2,600/2,600 | Mild preeclampsia + Hypothyroidism + cervical insufficiency | CS/CS |
| [12–14] | 1,5 | 4 | IVF/SC/SC | 5/24/59 | 3 | Girl/Girl/Boy | 38/41/40 | 3,204/3,828/ 4,015 | None/ None/ None | CS/ VD/ VD |
| [15] | nd | 4 | SC | 6 | 1 | Girl | 38 | 3,700 | nd | CS |
| [16, 17] | nd/nd | 4/nd | nd/nd | 5/nd | 2 | nd/nd | nd/nd | nd/nd | nd/nd | nd/nd |
| [17] | nd | 4 | SC | 8 | 1 | Boy | 38 | 3,089 | nd | nd |
| [18] | nd | 2 | IVF | 10–11 | 2 (twins) | Boy + Boy | 33 | 1,650 + 1,830 | None | CS |
| [19] | nd | 4 E2 > 110 FSH + LH <10 | SC | 9 | 1 | Boy | 38 | 2,830 | none | nd |
| [20, 21] | nd/nd/nd | nd/nd/nd | IVF | 10 | 1 | Boy | - | 3,026 | Cholecysto-lithiasis | nd |
| [22] | 1,8 | 5 E2 19 FSH 26 | IVF | 13 | 1 | Boy | 38 | 2,370 | nd | CS |
| [23] | nd | 3 E2 114 FSH 11 LH 4 | SC | 8 | 1 | Boy | 38 | 3,360 | None | CS |
| [24] | nd | nd | IVF | - | 1 | Boy | 37 | 3,254 | nd | nd |
| [25] | 4,3 | 3 E2 79 FSH 46 | SC | 16 | 1 | Girl | 39 | 3,970 | None | CS |
| [26] | 4,8/ 2,4 | 4.5 | IVF | 7 | 2 (twins) | Girl + Girl | 37 | 3,320 3,262 | nd | CS |
| [27] | nd | 5 E2 25 FSH >10 | IVF | 5 | 1 | Boy | 39 | 3,500 | nd | CS |
| [21] | 0,64/ nd | 6 FSH 10 | IVF | 14 | 1 | Girl | 37 | 2,030 | HELLP syndrome | VD |
| (case 1) | 3 | 4 FSH 7,5 | SC | 57 | 1 | Boy | 40 | 3,351 | None | VD |
/: symbolizes the number of autotransplantations or births
aas defined by resumption of spontaneous menstruation
bFSH and LH in IU/l; E2 in pg/ml
cAfter personal communication with CJ Stern it has been confirmed that the pregnancy resulted in a delivery of twin girls
Pregnancy
S: spontaneously conceived
IVF: after in vitro fertilization
ND: Not described
Delivery mode
CS: ceasarean section
VD: vaginal delivery
13 births worldwide from non peer-reviewed papers
Australia: Burmeister L, Kovacs GT and Osianlis T have published a case report of 1 ongoing pregnancy (Burmeister L, Kovacs GT, Osianlis T. First Australian pregnancy after ovarian tissue cryopreservation and subsequent autotransplantation. The Medical journal of Australia. 2,013;198(3):158–9.)
Through the media it is well known that the woman from this case report gave birth to a healthy baby girl in 2013, GA38 +
Sweden: 1 birth of a baby girl, mentioned in a newspaper, see attached link: http://www.dn.se/nyheter/vetenskap/historisk-bebis-ger-hopp/
South Africa: 1 birth of a baby boy, mentioned in a newspaper, see attached link: http://www.iol.co.za/capetimes/medical-method-bears-miracle-baby-1.1570087#.Us1MAZHDN8B
Germany: 3 undocumented births (confirmed from Fertiprotekt)
Israel: 5 undocumented births
Brussels: 2 undocumented births