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. 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4

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© Raithel et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A large number of patients with functional adverse food reactions were identified as carbohydrate malassimilation with/without small intestinal bowel overgrowth (SIBO), while a minority had non-allergic food intolerance or Irritable Bowel Syndrome (IBS). Among the remaining 225 patients an allergic disease could be excluded definitively, while 153 had strong clinical suspicion of gastrointestinally mediated allergy (GMA) and were scheduled for confirmatory food challenge tests. However, only in 56 patients completed diagnostics was obtained and this group with confirmation of allergy is further described as study group GMA.