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Anatomy of afadin molecule. The modular structure of l-afadin (a) and s-afadin (b) is schematically shown. Numbers in parentheses indicate the first and last amino acid of the structural domains. RA: Ras associated domain; FHA: forkhead associated domain; DIL: dilute domain; PDZ: postsynaptic density, Drosophila disk large tumor suppressor, zonula occludens-1 domain; PR: proline rich domain; F-actin: F-actin binding domain. PDZ domain interacts with nectin molecules.
