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. 2015 Apr 8;13:75. doi: 10.1186/s12916-015-0292-9

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© Slattery et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Major upstream regulators, TGFB1, MYC, and TP53 enriched by differentially expressed genes in our dataset. (a) TGFB1 upstream regulator of networks where the gene enrichment P values for differential expression was highly significant. (b) MYC primary upstream regulator of networks where the gene enrichment P value for differential expression was highly significant. (c) TP53 primary upstream regulator of networks where the gene enrichment P value for differential expression was highly significant.