TABLE 4.
Drug resistance
| Drug | Previous treatment for tuberculosis* | New tuberculosis |
|---|---|---|
| Isoniazid | 49/49 (100) | 44/44 (100) |
| Rifampin | 49/49 (100) | 44/44 (100) |
| Ethambutol | 28/49 (57.1) | 19/44 (43.2) |
| Pyrazinamide | 20/49 (40.8) | 14/44 (44) |
| Rifabutin | 28/45 (62.2) | 30/39 (76.9) |
| Streptomycin | 33/49 (67.4) | 33/44 (75.0) |
| Amikacin | 3/49 (6.1) | 1/44 (2.3) |
| Capreomycin | 1/49 (2.0) | 2/44 (4.6) |
| Any fluoroquinolone | 8/49 (16.3) | 2/44 (4.6) |
| Ofloxacin | 8/49 (16.3) | 2/44 (4.6) |
| Ciprofloxacin | 0/0 (0) | 0/1 (0) |
| Moxifloxacin | 0/2 (0) | 0/2 (0) |
| Ethionamide | 13/49 (26.5) | 13/44 (29.6) |
| Para-aminosalicylic acid | 0/18 (0) | 2/22 (9.1) |
| Clofazimine | 0/46 (0) | 1/42 (2.4) |
| Linezolid | 0/2 (0) | 0/2 (0) |
| Drugs resistant, n | ||
| 2 | 4 (8.2) | 0 (0) |
| 3 | 8 (16.3) | 10 (22.7) |
| 4 | 12 (24.5) | 13 (29.6) |
| 5 | 9 (18.4) | 7 (15.9) |
| 6 | 8 (16.3) | 10 (22.7) |
| 7 | 5 (10.2) | 4 (9.1) |
| 8 | 3 (6.1) | 0 (0) |
| Drugs resistant, mean ± SD | 4.7±1.7 | 4.7±1.3 |
| XDR tuberculosis | 0 (0)† | 0 (0) |
Data presented as number resistant/number tested (%) or n (%) unless otherwise indicated.
*
Patient self-report of previous tuberculosis (TB) treatment;
†
One patient presented to the authors institution initially with multidrug-resistant TB plus fluoroquinolone resistance but stopped treatment and was lost to follow-up after five months of treatment. He presented again to the authors’ institution one month after being ‘lost’, was again culture positive and had developed amikacin resistance (extensively drug-resistant [XDR] TB), which was successfully treated