Table 4.
Total retinol and α-retinol in rat liver, kidney, and serum after given 3.5 µmolα-retinyl acetate/day for 21 days. All groups were fed a vitamin A-deficient diet for 3 weeks. Rats were killed on d 1, 8, and 15 after the final dose. Control rats were given cottonseed oil alone*
| Time | Control | Day 1 | Day 8 | Day 15 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROH | αR | ROH | αR | ROH | αR | ROH | αR | |||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Liver (nmol/g) | 1·47 | 1·11c | 2·1 | 3·64c | 24·5 | 7·57a | 2300 | 227a | 18·8 | 6·45b | 1750 | 208b | 20·4 | 4·08ab | 1770 | 150b |
| Kidney (nmol/g) | 6·88 | 4·32a | 0·31 | 0·20b | 7·00 | 4·69a | 3·96 | 2·08a | 2·31 | 0·51b | 1·99 | 0·37b | 2·85 | 0·50ab | 1·83 | 0·39b |
| Serum, alcohol form (µmol/l) | 0·81 | 0·39a | 0·01 | 0·02c | 0·67 | 0·05a | 0·05 | 0·01b | 0·58 | 0·14a | 0·07 | 0·02a | 0·71 | 0·11a | 0·08 | 0·01a |
| Serum, ester form (µmol/l) | ND2 | ND | ND | 0·08 | 0·01b | ND | 0·10 | 0.01ab | ND | 0·11 | 0·02a | |||||
αR, α-retinol; ROH, retinol.
Data represent mean(SD), n 5 for rats for d 1, 8, and 15 timepoints, and n 3 for the control group.
Superscript letters within each row indicate a difference (P < 0.05) in concentration of retinol or α-retinol (αR) between timepoints.
ND, not detected.