Table 3.
Results of selected BMT reports using different strategies for allogeneic transplantation in patients with sickle cell disease: myeloablation and non-myeloablation.
| Alternative donors | |||
|---|---|---|---|
| Cord | Cord | Haploidentical non-myeloablative | |
| Ruggeri (25) | Kamani (24) | Bolaños Meade (13) | |
| Number of patients | 16 | 8 | 17 |
| OS | 94% | 87% | 100% |
| EFS | 50% | 25% | 57% |
| TRM | 6% | 13% | 0 |
| Graft failure | 43% | 63% | 43% |
| Ages | Median 6 | Median 13 | 15–46 |
| Acute GvHD | 11* | 2 | 1 |
| Chronic GvHD | 10* | 1 | 0 |
| Comments | Retrospective registry study | High rejection rate | Small prospective study |
*
The report does not specify if the patients who developed GvHD had thalassemia or sickle cell disease or a mix.