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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Methods Appl Fluoresc. 2015 Jan 16;3(1):014003. doi: 10.1088/2050-6120/3/1/014003

Figure 9.

Figure 9

Illustration of a pyramid registration scheme. Pairs of particles are registered to each other and combined to form the next layer of the pyramid. The process is repeated until one particle remains which is the final average. This procedure scales quadratically with the number of particles.