Table 2.
Hypersensitivity reactions after total joint arthroplasty in retrospective studies.
| Retrospective study title | Publication | Author | Results |
|---|---|---|---|
| Contact allergy to metals and bone cement components in patients with intolerance of arthroplasty | Dtsch Med Wochenschr | Eben et al. [15] | In cemented TJA: 22/66 symptomatic pts. patch +, asymptomatic patch + 3/26 |
| Allergy to metals as a cause of orthopaedic implant failure | Int J Occup Med Environ Health | Kręcisz et al. [16] | 14 poor implants, 8 patch + (7 ni, 6 cr), 3 underwent revision and improved |
| Early osteolysis following second-generation metal-on-metal hip-replacement | J Bone Joint Surg Am | Park et al. [17] | 8/9 MoM w/osteolysis patch + to Co, 2/9 w/o osteolysis patch +; retrospective |
| Sensitivity to metal as a possible cause of sterile loosening after cobalt-chromium total hip-replacement arthroplasty | J Bone Joint Surg Am | Brown et al. [18] | 0/20 loose MoM patch + (1977) |
| Metal sensitivity as a cause of bone necrosis and loosening of the hip prosthesis in total joint replacement | J Bone Joint Surg Br | Evans et al. [2] | 9/14 w/loose joints patch +, 0/24 w/stable joints |
| Incidence of metal sensitivity in patients with total joint replacements | Br Med J | Elves et al. [1] | 15/23 failed TJA patch +, 4/27 stable patch +, 8/13 w/derm rxn were patch + |
| Dermatitis on the knee following knee replacement: a minority of cases contact allergy to chromate, cobalt, or nickel but a causal association is unproven | Contact Dermatitis | Verma et al. [12] | 7 of 15 patients w/cutaneous symptoms patch + |
| Metal sensitivity in patients with metal-to-plastic total hip arthroplasties | Acta Orthop Scand | Carlsson et al. [11] | 13/134 MOP patch + postop.; unsure if hypersensitivity caused by THA, but, in pts. w/Hx of allergy, proceed w/caution |
| Retrospective evaluation of patch testing before or after metal device implantation | Arch Dermatol | Reed et al. [13] | 5/22 with history of hypersensitivity preop. patch +, 0/22 referred for patch test postop. were patch + |
| Lymphocyte responses in patients with total hip arthroplasty | J Orthop Res | Hallab et al. [14] | More + LTT and cytokine release in THA, and esp. in loose THA |
|
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| Retrospective study summary | Revised: 33/138 (23.9%) patch +, 44/303 (14.5%) patch + in stable TJA Failed/loose: 113/261 (43.3%) patch +, 32/146 (21.9%) patch + in TJA Total: 146/399 (36.6%) patch +, 76/449 (16.9%) patch − 10/16 (62.5%) revised TJAs LTT + |
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