Table 2.
List of experimentally validated miRNA—gene interactions for Wnt signalling pathway. Interactions with Notch and TGF-β signalling are also indicated (genes among those in Wnt pathway).
| miRNA | Gene (Wnt pathway) | Notch signalling | TGF-β signalling |
|---|---|---|---|
| hsa-miR-335-5p | CTNNBIP1, LRP6, TBL1X, WNT10B, CCND2, DKK2, SMAD3, AXIN1, WNT3, FZD8, PPP2R5A, NFAT5, FZD10, MYC, VANGL2, PRKCG, DKK4, FZD1, PRICKLE2, SFRP1, WIF1, DAAM1, WNT7B, WNT9A, PPP3R2 | — | SMAD3, MYC |
|
| |||
| hsa-miR-34a-5p | WNT1, CCND1, CTNNB1, AXIN2, MYC, PPP3R1, LEF1, MAP3K7, CCND3 | — | MYC |
|
| |||
| hsa-miR-1 | CSNK2A2, CAMK2G, CTBP1, CTBP2, PPP2R5A, PLCB3, CCND1, DKK1 | CTBP1, CTBP2 | — |
|
| |||
| hsa-miR-124-3p | VANGL1, PORCN, ROCK2, RHOA, WNT5B, CTNNB1, PPP2R1B, NFATC1, DVL2 | DVL2 | ROCK2, PPP2R1B, RHOA |
|
| |||
| hsa-miR-26b-5p | SFRP4, DVL3, FZD5, RUVBL1, VANGL1, GPC4, JUN, CCND1, VANGL2, PPP3R1, EP300, PLCB4, PLCB2 | EP300, DVL3 | EP300 |
|
| |||
| hsa-miR-155-5p | GSK3B, SMAD2, APC, VANGL1, WNT5A, SMAD3, CSNK1A1L, RHOA, CTNNB1, CSNK1A1, RAC1, PSEN1 | PSEN1 | SMAD2, SMAD3, RHOA, |
|
| |||
| hsa-miR-375 | PRKCA, RHOA, FZD4, PRKX | — | RHOA |
|
| |||
| hsa-miR-21-5p | TCF4, APC, WNT1, WNT5A, NFAT5, CSNK1A1, MYC, PRICKLE2, DAAM1, TBL1XR1 | — | MYC |
|
| |||
| hsa-miR-98 | VANGL1, WNT10B, SENP2, FZD10, MYC | — | MYC |
|
| |||
| hsa-miR-122-5p | RHOA, RAC1, TBL1XR1 | RHOA | RHOA |
|
| |||
| hsa-miR-200c-3p | TCF7L1, EP300 | EP300 | EP300 |
|
| |||
| hsa-miR-9-5p | WNT8A, WNT6, EP300, NFATC3, PLCB4 | EP300 | EP300 |
|
| |||
| hsa-miR-324-3p | WNT9B, CREBBP, DVL2 | CREBBP, DVL2 | CREBBP |
|
| |||
| hsa-miR-24-3p | FZD5, CHD8, FZD4, NFAT5, NKD1, MYC, PPP3R1 | — | MYC |
|
| |||
| hsa-miR-194-5p | EP300 | EP300 | EP300 |
|
| |||
| hsa-miR-92a-3p | SMAD4 | — | SMAD4 |
|
| |||
| hsa-miR-16-5p | CAMK2G, WNT5A, CCND2, PPP2R5C, JUN, CCND1, AXIN2, PPP2R1A, WNT3A, CCND3 | — | PPP2R1A |
|
| |||
| hsa-miR-93-5p | MAPK9, CCND1, PRKACB | — | — |
|
| |||
| hsa-miR-19a-3p | CCND1, SMAD4 | — | SMAD4 |
|
| |||
| hsa-miR-103a-3p | AXIN2, WNT3A, MAP3K7 | — | — |
|
| |||
| hsa-miR-132-3p | WNT3A | — | — |
|
| |||
| hsa-miR-30a-5p | WNT5A, PPP2R5C, PPP3CA, JUN, CTNNB1, PPP3R1 | — | — |
|
| |||
| hsa-miR-200b-3p | TCF7L1, EP300 | EP300 | EP300 |
|
| |||
| hsa-miR-19b-3p | DAAM2, TCF4, CCND2, SMAD4, PRKACB | — | SMAD4 |
|
| |||
| hsa-miR-145-5p | PPP3CA, MYC | — | MYC |
|
| |||
| hsa-miR-31-5p | RHOA, NFAT5 | — | RHOA |
|
| |||
| hsa-miR-429 | TCF7L1, EP300 | EP300 | EP300 |
|
| |||
| hsa-miR-10a-5p | BTRC, MAPK8, MAP3K7 | — | — |
|
| |||
| hsa-miR-182-5p | EP300 | EP300 | EP300 |
|
| |||
| Hsa-miR-374a-5p | EP300 | EP300 | EP300 |