Table 3.
Frequencies of Genotypes of rs7754840 (CDKAL1), rs864745 (JAZF1), and rs35767 (IGF1) in T2DM Participants and Controls
| Logistic regression analysis (adjusted for age and BMI)c | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T2DM | Control | Chi-square test | Additive | Dominant | Recessive | ||||||
| SNP | Genotype | No. (%) | No. (%) | Chi-square | P | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) |
| rs7754840 (CDKAL1) | GG | 15 (29.4) | 30 (58.8) | 17.448 | <0.001 | 0.014 | 2.32 (1.19–4.54) | 0.035 | 1.63 (1.04–2.57) | 0.057 | 1.99 (0.98–3.99) |
| GC | 25 (49.0) | 18 (35.3) | |||||||||
| CC | 11 (21.6) | 3 (5.9) | |||||||||
| rs864745a (JAZF1) | TT | 24 (49.0) | 20 (39.2) | 5.946 | 0.051 | 0.032 | 0.48 (0.24–0.94) | 0.160 | 0.73 (0.46–1.14) | 0.025 | 0.39 (0.17–0.89) |
| TC | 22 (44.9) | 19 (37.3) | |||||||||
| CC | 3 (6.1) | 12 (23.5) | |||||||||
| rs35767b (IGF1) | GG | 21 (42.0) | 34 (66.7) | 6.853 | 0.033 | 0.044 | 2.06 (1.02–4.17) | 0.014 | 1.75 (1.12–2.75) | 0.829 | 1.09 (0.49–2.44) |
| GA | 25 (50.0) | 13 (25.5) | |||||||||
| AA | 4 (8.0) | 4 (7.8) | |||||||||
a
The number of T2DM participants is 49, due to two samples failed to call out the genotypes; bThe number of T2DM participants is 50, due to one sample failed to call out the genotypes; cThe logistic regression model was used to obtain the odds ratios of the minor allele with the major allele as reference group.
The p values with statistical significance are indicated in bold numbers.