Table 5. Immunophenotype comparison of common WM models with various B/plasma cell cancers.
| B/plasma cell malignancies | WM models | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Antigen | LPL/WM | SMZL | CLL | MCL | FL | HCL | MALT | MM | RPCI-WM1 | BCWM.1 | MWCL-1 |
| CD5 | - | + | + | + | - | - | - | - | - | - | + |
| CD10 | - | - | - | - | + | - | - | - | - | - | - |
| CD11C | + | + | - | + | + | + | + | - | - | - | - |
| CD19 | +/- | + | + | +/- | +/- | - | + | - | - | + | + |
| CD20 | +/- | + | + | + | + | + | + | - | - | + | + |
| CD23 | +/- | + | + | - | + | - | - | +/- | + | - | + |
| CD25 | +/- | + | - | - | - | + | - | - | + | + | + |
| CD27 | +/- | + | + | + | + | - | + | - | - | - | - |
| CD38 | + | +/- | + | + | + | - | +/- | + | + | + | + |
| CD138 | + | +/- | - | - | - | - | +/- | + | + | + | + |
Abbreviations: +, present in >20% gated cells;-, present in <20% of gated cells; LPL/WM, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia; SMZL, splenic marginal zone lymphoma; CLL, chronic lymphocytic leukemia; MCL, mantle cell lymphoma; FL, follicular lymphoma; HCL, hairy cell leukemia; MALT, mucosa-associated lymphoid tissue; MM, multiple myeloma.