Table 3. Associations between principal component (PC) scores and outcome.

		PC1			PC2
		Mean (SE)	Delta †	p-value	Mean (SE)	Delta †	p-value
Mortality (2 weeks) †	Alive	0.09 (0.12)	-0.95	0.01	0.01 (0.09)	-0.05	0.8
	Dead	-0.49 (0.44)			-0.08 (0.13)
IRIS ¶	No IRIS	0.14 (0.12)	-0.08	0.3	0.12 (0.09)	-0.63	0.004
	IRIS	-0.25 (0.48)			-0.75 (0.18)

^†The adjusted p values shown were derived from a linear regression model adjusting for treatment group, CD4⁺-cell count, and the previously described risk factors for mortality, baseline fungal burden and altered mental status. The adjusted delta is the β-coefficient derived from the adjusted linear regression model. Unadjusted p-values were 0.09 (PC1) and 0.7 (PC2).

^¶The association between PC2 and IRIS remained significant in both the linear regression model adjusting for treatment group, CD4⁺-cell count, and the previously described risk factors for mortality, baseline fungal burden and altered mental status, as described above (p = 0.004), and a linear regression model (results shown in table) adjusting for treatment group and the known risk factors for IRIS, baseline fungal burden and CSF white cell count (p = 0.004). Unadjusted p-value = 0.001. The adjusted delta is the β-coefficient derived from the adjusted linear regression model.