Table 2.
Pathway Analysis of Up- and Down-Regulated Genes Only in Thyroidectomized Side Population Cells Versus Non–Side Population Cells
| Top biological functions | p-value | No. of molecules |
|---|---|---|
| Diseases and disorders | ||
| Cancer | 8.50E-05 to 2.95E-02 | 281 |
| Reproductive system disease | 8.50E-05 to 2.90E-02 | 95 |
| Hematological disease | 1.94E-04 to 1.86E-02 | 11 |
| Immunological disease | 1.94E-04 to 2.09E-02 | 14 |
| Genetic disorder | 3.10E-04 to 2.94E-02 | 286 |
| Molecular and cellular functions | ||
| Cellular growth and proliferation | 3.87E-05 to 2.95E-02 | 231 |
| Cell death | 4.40E-05 to 2.88E-02 | 203 |
| Cell-to-cell signaling and interaction | 8.50E-05 to 2.62E-02 | 93 |
| Cellular movement | 1.27E-04 to 2.95E-02 | 116 |
| Cell morphology | 2.31E-04 to 2.95E-02 | 113 |
| Physiological system development and function | ||
| Tissue development | 1.95E-04 to 2.88E-02 | 130 |
| Connective tissue development and function | 2.31E-04 to 2.92E-02 | 39 |
| Organismal development | 2.41E-04 to 2.88E-02 | 85 |
| Cardiovascular system development and function | 3.40E-04 to 2.88E-02 | 13 |
| Hepatic system development and function | 3.40E-04 to 1.86E-02 | 6 |