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SOAE inhibits NF-kappaB transcription and translocation. PCR array results showed that SOAE inhibited LPS-induced NF-kappaB mRNA levels in RAW 264.7 cells (A). Immunofluorescence staining revealed that SOAE inhibited NF-kappaB translocation to the nucleus in both macrophages (B, upper panel) and HUVECs (B, lower panel). Images are at 100× and are representative of three independent experiments.
