Table 4. HLA-G 14 bp genotype in relation to sHLA-G levels in adult patient groups and healthy controls.

			RA	HC		RA	HC
HLA-G genotype	N (%) RA	N (%) HC	sHLA-G a (range b )	sHLA-G a (range b )	Pbonf c	LILRB1 recognition d (range e )	LILRB1 recognition d (range e )	Pbonf c
del/del	22 (32)	11 (42)	6.4 (1.5–131.9)	5.5 (1.6–11.0)	0.178	0 (0–155.9)	17.3 (0–212.2)	0.074
del/ins	37 (55)	11 (42)	10.6 (0.5–104.6)	5.9 (0.8–20.4)	0.013	16.1 (0–117.1)	14.7 (0–169.2)	0.970
ins/ins	9 (13)	4 (15)	5.5 (1.0–59.5)	0.7 (0–2.1)	0.020	50.8 (0–201.0)	3.8 (0–24.6)	0.148
P-value	0.567 f		0.534 g	0.018 g		0.200 g	0.182 g

^amedian in ng/ml

^b(minimum—maximum sHLA-G in ng/ml)

^cComparison between patients and controls of the same genotype, Mann Whitney test

^dmedian in units/ml (measured by LUMINEX)

^e(minimum—maximum fluorescence intensity)

^fComparison of genotype frequencies between patients and controls, Chi-square test

^gComparison among genotypes, Kruskall-Wallis test

HC = healthy controls