Fig. 1.

Deep analysis of plasma microparticle proteomes. A, Triplicate single runs of microparticle proteomes identified 3689 proteins ranging from albumin to cytokines. B, Single run of unfractionated plasma identified 451 proteins. Selected tissue-leakage proteins are marked in blue dots; core plasma proteins are marked in red dots. C, Numeric comparison between different methods. Venn diagram showing the overlap between the proteins identified in single LC-MS/MS run, triplicate single runs, and the plasma proteins included in the Peptide Atlas (127 studies) (29).