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. 2015 Jan 23;14(4):870–881. doi: 10.1074/mcp.M114.044552

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 6. — Hypothetical model for arginine sensing in the phagosome. Francisella responds to variations of arginine availability in the phagosomal environment by regulating ribosomal protein biogenesis. In wild-type Francisella (WT, upper panel), import of arginine mediated by the transporter ArgP, promotes ribosomal protein synthesis (R), a pre-requisite for efficient protein (P) syntheses, a pre-requisite for membrane disruption and cytosolic escape. In the absence of ArgP (lower panel), ribososomal protein synthesis is down-regulated (R), impairing thus protein syntheses (P), leading to impaired bacterial escape.

Inline graphic — Hypothetical model for arginine sensing in the phagosome. Francisella responds to variations of arginine availability in the phagosomal environment by regulating ribosomal protein biogenesis. In wild-type Francisella (WT, upper panel), import of arginine mediated by the transporter ArgP, promotes ribosomal protein synthesis (R), a pre-requisite for efficient protein (P) syntheses, a pre-requisite for membrane disruption and cytosolic escape. In the absence of ArgP (lower panel), ribososomal protein synthesis is down-regulated (R), impairing thus protein syntheses (P), leading to impaired bacterial escape.