Table I. List of 30 candidate proteins with twofold higher levels (q<0.05) in NSCLC-MPE than two benign PEs.
| Protein name | Gene symbol | Swiss-Prot Acc. No. | M.W. (kDa) | NSCLC-MPE/TB log2 ratio | NSCLLC-MPE/PN log2 ratio | NSCLC-MPE/NSCLC-PMPE log2 ratio | mRNA Data set numbera | Up-regulated mRNA data set number (p value < 0.05)b |
|---|---|---|---|---|---|---|---|---|
| Mucin-1 | MUC1 | MUC1_HUMAN | 122 | 4.77 | 4.70 | 3.33 | 10 | 4 |
| Pulmonary surfactant-associated protein B | SFTPB | PSPB_HUMAN | 42 | 3.80 | 1.86 | 2.40 | 9 | 1 |
| Mimecan | OGN | MIME_HUMAN | 34 | 3.71 | 1.19 | 0.57 | 6 | 0 |
| Receptor-type tyrosine-protein phosphatase F | PTPRF | PTPRF_HUMAN | 213 | 3.62 | 3.99 | 2.44 | 10 | 8 |
| CD166 antigen | ALCAM | CD166_HUMAN | 65 | 3.41 | 3.34 | 3.21 | 10 | 0 |
| Carcinoembryonic antigen-related cell adhesion molecule 5 | CEACAM5 | CEAM5_HUMAN | 77 | 3.11 | 3.03 | 0.31 | 9 | 9 |
| Kunitz-type protease inhibitor 1 | SPINT1 | SPIT1_HUMAN | 58 | 2.92 | 2.85 | 2.72 | 7 | 6 |
| Polymeric immunoglobulin receptor | PIGR | PIGR_HUMAN | 83 | 2.38 | 1.92 | 2.74 | 8 | 2 |
| Intelectin-1 | ITLN1 | ITLN1_HUMAN | 35 | 2.26 | 2.18 | 1.08 | 5 | 0 |
| Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 | SVEP1 | SVEP1_HUMAN | 390 | 2.22 | 1.81 | 0.99 | 8 | 2 |
| Membrane primary amine oxidase | AOC3 | AOC3_HUMAN | 85 | 2.22 | 1.32 | 0.67 | 9 | 0 |
| 3,2-trans-enoyl-CoA isomerase, mitochondrial | DCI | D3D2_HUMAN | 33 | 2.18 | 2.11 | 1.97 | 9 | 5 |
| Antileukoproteinase | SLPI | SLPI_HUMAN | 14 | 2.06 | 1.23 | 1.85 | 9 | 0 |
| Interleukin-1 receptor accessory protein | IL1RAP | IL1AP_HUMAN | 65 | 2.05 | 1.97 | 1.84 | 8 | 4 |
| Thy-1 membrane glycoprotein | THY1 | THY1_HUMAN | 18 | 2.00 | 1.92 | 2.50 | 9 | 8 |
| CD9 antigen | CD9 | CD9_HUMAN | 25 | 1.93 | 1.85 | 1.72 | 10 | 3 |
| Mucin-5B | MUC5B | MUC5B_HUMAN | 591 | 1.89 | 1.82 | 1.69 | 9 | 7 |
| Carbonic anhydrase 3 | CA3 | CAH3_HUMAN | 30 | 1.89 | 1.40 | 2.24 | 10 | 0 |
| Cartilage intermediate layer protein 1 | CILP | CILP1_HUMAN | 133 | 1.74 | 3.20 | 3.07 | 7 | 7 |
| Neogenin | NEO1 | NEO1_HUMAN | 160 | 1.66 | 1.16 | 2.64 | 10 | 0 |
| Hepatocyte growth factor receptor | MET | MET_HUMAN | 156 | 1.66 | 1.58 | 1.45 | 9 | 5 |
| Claudin-4 | CLDN4 | CLD4_HUMAN | 22 | 1.65 | 1.57 | 1.44 | 8 | 8 |
| Tyrosine-protein kinase-like 7 | PTK7 | PTK7_HUMAN | 118 | 1.64 | 1.56 | 1.43 | 10 | 7 |
| Intercellular adhesion molecule 1 | ICAM1 | ICAM1_HUMAN | 58 | 1.48 | 1.67 | 3.47 | 8 | 0 |
| Deleted in malignant brain tumors 1 protein | DMBT1 | DMBT1_HUMAN | 261 | 1.48 | 1.41 | 1.27 | 7 | 0 |
| Latent-transforming growth factor beta-binding protein 2 | LTBP2 | LTBP2_HUMAN | 195 | 1.38 | 3.84 | 1.31 | 9 | 0 |
| Thrombospondin-4 | THBS4 | TSP4_HUMAN | 106 | 1.33 | 3.18 | 1.62 | 9 | 6 |
| Alpha-amylase 1 | AMY1A | AMY1_HUMAN | 58 | 1.27 | 1.19 | 1.06 | 5 | 2 |
| Mesothelin | MSLN | MSLN_HUMAN | 69 | 1.25 | 1.18 | -0.37 | 9 | 0 |
| Dipeptidyl peptidase 4 | DPP4 | DPP4_HUMAN | 88 | 1.12 | 1.01 | 1.65 | 9 | 7 |
a The data were taken from the Oncomine 4.4.4.4 Research Edition (https://www.oncomine.org/resource/login.html).
b The regulation of expression indicate the mRNA levels in NSCLC tissues Compared to noncancerous tissues.