Table 2.

Risk estimates and predicted miRNAs for the 22 putative miRSNPs associated with prostate cancer risk

miRSNP	Gene	Transcript variante	Predicted miRNA(s)c	chr	position	Risk OR (95% CI)d	Risk p-value
rs4245739	MDM4a	NM_002393, NM_001204171, NM_001204172	miR-191-5p, miR-887, miR-3669	1	204518842	0.92 (0.89–0.95)	7.81E-08
rs4233979	TMEM17	NM_198276	miR-299-5p	2	62727902	1.08 (1.04–1.12)	1.61E-05
rs1010	VAMP8b	NM_003761	miR-370, miR-103	2	85808982	0.91 (0.89–0.94)	3.79E-11
rs17664	ITGA6b	NM_001079818, NM_000210	miR-548c-3p miR-548aj, miR-4691-3p	2	173369231	0.93 (0.91–0.96)	5.51E-07
rs1530865	PDK1	NM_002610	miR-877-5p, miR-3125, miR-3916	2	173461090	0.8 (0.75–0.86)	2.28E-09
rs2357637	PDK1	NM_002610	miR-3916, miR-3125, miR-877-5p	2	173463138	0.81 (0.76–0.88)	3.66E-08
rs7615039	PHC3	NM_024947	miR-208a, miR-208b	3	169806170	0.86 (0.83–0.9)	8.72E-12
rs12492606	PHC3	NM_024947	miR-939, miR-362-5p	3	169808354	0.86 (0.83–0.9)	1.23E-11
rs879161	PHC3	NM_024947	miR-27a-5p, miR-220c, miR-3158-3p	3	169812115	0.86 (0.83–0.9)	6.57E-12
rs14082	PDLIM5b	NM_006457, NM_001011513, NM_001256425, NM_001256426, NM_001256428	miR-128, miR-494	4	95586224	1.09 (1.06–1.12)	1.27E-09
rs1043853	PDLIM5b	NM_006457, NM_001011513, NM_001256425, NM_001256426, NM_001256427, NM_001256428	miR-567, miR-3120, miR-4310	4	95588274	1.08 (1.05–1.11)	9.65E-09
rs2647257	TET2b	NM_001127208	miR-301a, miR-301b, miR-4330	4	106199505	1.1 (1.06–1.13)	2.05E-10
rs2450975	SLC22A2b	NM_003058, NM_003058	miR-412, miR-4282	6	160637975	1.12 (1.09–1.16)	9.36E-13
rs3127593	SLC22A2b	NM_003058	miR-200a miR-302a miR-488-3p	6	160638003	1.12 (1.08–1.17)	2.22E-08
rs3103353	SLC22A2b	NM_003058	miR-942, miR-4268	6	160638076	1.12 (1.08–1.17)	1.75E-08
rs1810126	SLC22A3b	NM_021977	miR-1205, miR-124-3p, miR-216b	6	160872151	1.1 (1.07–1.13)	2.81E-11
rs1567669	NKX3-1b	NM_006167, NM_001256339	miR-637, miR-1275, miR-625	8	23538533	1.11 (1.08–1.15)	3.15E-13
rs12573077	ARL3	NM_004311	miR-432, miR-1258, miR-1224-5p	10	104434630	0.93 (0.91–0.96)	6.43E-06
rs1058205	KLK3a	NM_001648, NM_001030047, NM_001030048	miR-3162-5p, miR-219-1-3p, miR-4278	19	51363398	0.87 (0.83–0.9)	1.73E-14
rs311497	GMEB2	NM_012384	miR-26c, miR-492, miR-619, miR-4648	20	62221249	0.92 (0.89–0.94)	1.28E-09
rs7402	MCAT	NM_173467, NM_014507	miR-616-3p	22	43529029	0.93 (0.91–0.96)	4.41E-06
rs47340	TTLL12	NM_015140	let-7f, let-7g, let-7i, miR-103, miR-107, miR-764	22	43562829	1.07 (1.04–1.1)	5.79E-06

^aSNP previously identified in prostate cancer GWAS and fine-mapping studies.

^bOther SNPs within or around the genes for the listed SNPs have been identified in previous GWAS studies.

^cmiRNAs were predicted using four algorithms. (See Materials & Methods).

^dadjusted for 6 principal components and study group.

^emiRSNPs are present within the 3′UTRs of the most the of the common splice variants of the miRNA target genes