TABLE 2.

Synaptic impact of ADDLs

Synaptic defects		Refs
	Alterations in neurotransmitter release/uptake	-(Li et al., 2009) -(Brito-Moreira et al., 2011)
Changes in receptor levels or localization	Internalization of NMDARs	-(Snyder et al., 2005) -(Goto et al., 2006) -(Lacor et al., 2007) -(De Felice et al., 2009) -(Jurgensen et al., 2011)
	Internalization of AMPARs	-(Almeida et al., 2005) -(Roselli et al., 2005) -(Hsieh et al., 2006) -(Zhao et al., 2010) -(Jurgensen et al., 2011)
	Internalization/degr adation of EphB receptors	-(Lacor et al., 2007) -(Cisse et al., 2011)
	Internalization of insulin receptors	-(Zhao et al., 2008) -(De Felice et al., 2009)
Impairment of plasticity	Inhibition of LTP	-(Lambert et al., 1998) -(Walsh et al., 2002) -(Townsend et al., 2006) -(Shankar et al., 2008) -(Klyubin et al., 2008) -(Nimmrich et al., 2008) -(Lauren et al., 2009) -(Oliveira et al., 2010) -(Dineley et al., 2010) -(Ronicke et al., 2010) -(Jurgensen et al., 2011) -(Shipton et al., 2011)
	Facilitation /potentiation of LTD	-(Wang et al., 2002) -(Cerpa et al., 2010) -(Shankar et al., 2008) -(Li et al., 2009) -(Origlia et al., 2010)
	Cytoskeletal abnormalities	-(Lacor et al., 2004a) -(Whalen et al., 2005) -(Fifre et al., 2006) -(Lacor et al., 2007)
	Synapse deterioration /elimination	-(Lacor et al., 2007) -(Shankar et al., 2007) -(Shankar et al., 2008) -(De Felice et al., 2009) -(Zhao et al., 2010) -(Tomiyama et al., 2010)