Table 4.

Effect of change in ROI (ΔROI)^† at each visit from baseline on hazard of AD and on hazard ratio (HR_p) for anxiety. (ICV = intracranial volume, HC = hippocampus, EC = entorhinal cortex)

Region of interest (ROI)	HRp	Wald z-value	p-value	HRp for Anxiety with inclusion of ΔROI in the modelδ
ΔICV (mL)*	1.01	+1.57	0.12	1.27
ΔHC (mL)	0.33	−1.09	0.28	1.27
ΔAmygdala (mL)	0.27	−0.98	0.33	1.28
ΔEC volume (mL)	0.08	−2.23	0.03	1.29
ΔEC thickness (mm)	0.12	−3.28	0.001	1.29
ΔEC surface area (cm2)	0.74	−0.78	0.43	1.27

^†see text for calculation of ΔROI

^*included in all models

^δCox proportional-hazards models (130 events, n=332) additionally included sex, education, baseline memory, baseline executive function (see text).