Table 5.
Mean (and standard deviation) for rate of change (Ratrophy) in AD structural neuroimaging biomarkers by anxiety status in aMCI. (ICV = intracranial volume, HC = hippocampus, EC = entorhinal cortex)
| Ratrophy within region of interest | MCI anxiety− | MCI anxiety+ | t-statistic† |
|---|---|---|---|
| Number | 132 | 104 | |
| ICV | +1.78 (sd = 7.43) | +2.34 (sd = 6.69) | +0.55 (p = 0.58) |
| HC volume | −0.072 (sd = 0.054) | −0.086 (sd = 0.053) | −1.36 (p = 0.18) |
| Amygdala volume | −0.023 (sd = 0.035) | −0.022 (sd = 0.035) | +0.35 (p = 0.73) |
| EC volume | −0.020 (sd = 0.047) | −0.070 (sd = 0.049) | −2.55 (p = 0.01) |
| EC thickness | −0.078 (sd = 0.080) | −0.106 (sd = 0.084) | −1.93 (p = 0.0546) |
| EC surface area | −0.035 (sd = 0.097) | −0.047 (sd = 0.104) | −0.68 (p = 0.50) |
†
conversion status included as a covariate, df = 233