Table 2.

Drug related toxicities: dose escalation phase: AZA/belinostat

Toxicity	75/150 (n=6)	75/300 (n=5)	75/600 (n=6)	75/1000 (N=7)
Hematologic
Grade 1/2	0	1	3	1
Grade 3/4	1	1	1	2
Fatigue
Grade 1/2	3	1	4	2
Grade 3/4	0	0	0	0
Injection Site Reaction
Grade 1/2	2	3	4	3
Grade 3/4	0	0	0	0
Flushing
Grade 1/2	0	0	1	1
Grade 3/4	0	0	0	0
Nausea/Vomiting
Grade 1/2	3	3	5	5
Grade 3/4	0	0	0	0
Constipation
Grade 1/2	2	1	3	1
Grade 3/4	0	0	0	0
Anorexia
Grade 1/2	1	1	1	4
Grade 3/4	0	0	0	0
Diarrhea
Grade 1/2	2	0	1	1
Grade 3/4	0	1	0	0
Neuropathy
Grade 1/2	0	1	1	1
Grade 3/4	0	0	0	0
Prolonged QT
Grade 1/2	4	0	1	0
Grade 3/4	0	1	0	0