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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Invest New Drugs. 2014 Dec 9;33(2):371–379. doi: 10.1007/s10637-014-0194-2

Table 3.

Drug related toxicities: randomization phase

Toxicity AZA alone
n=18
AZA/belinostat
n=14

Hematologic
 Grade 1/2 2 1
 Grade 3/4 4 3

Fatigue
 Grade 1/2 10 9
 Grade 3/4 0 0

Injection Site Reaction
 Grade 1/2 7 7
 Grade 3/4 0 0

Nausea/Vomiting
 Grade 1/2 13 11
 Grade 3/4 0 0

Anorexia
 Grade 1/2 4 3
 Grade 3/4 0 0

Diarrhea
 Grade 1/2 4 4
 Grade 3/4 0 0

Prolonged QT
 Grade 1/2 2 3
 Grade 3/4 0 1

Dizziness
 Grade 1/2 5 1
 Grade 3/4 0 0

LFT abnormality
 Grade 1/2 2 0
 Grade 3/4 0 1

Hypotension
 Grade 1/2 4 1
 Grade 3/4 0 0

Mucositis
 Grade 1/2 2 1
 Grade 3/4 0 0