Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Invest New Drugs. 2014 Nov 29;33(2):480–489. doi: 10.1007/s10637-014-0189-z

Table 2. Pharmacokinetic parameters of sulforaphane and metabolites.

Data is presented as mean ± S.D. or median (25%, 75%).

	All	Null/Null	+/+ or +/Null
SFN
AUC_0-inf (h*ng/mL)	121.6 ± 36.1	115.1 (96.6, 139.8)	114.4 (97.8, 128.5)
C_max (ng/mL)	36.7 ± 9.8	35.8 ± 9.5	37.3 ± 10.3
T_max (h)	1.47 ± 0.78	1.02 (0.90, 2.00)	1.02 (1.00, 2.00)
T_1/2 (h)	2.55 ± 0.95	2.59 (2.18, 3.9)	2.09 (1.91, 2.39)^#
CL/F (L/h)	315 ± 84	308 ± 76	319 ± 93
V_z (L)	1196 ± 676	931 (822, 2099)	1029 (792, 1249)
SFN-CYS
AUC_0-inf (h*ng/mL)	514. 4 ± 146.9	494.8 ± 173.7	527.4 ± 132.7
C_max (ng/mL)	165.2 ± 48.6	159.8 ± 62.7	168.8 ± 39.3
T_max (h)	1.58 ± 0.78	1.51 (0.90, 2.02)	1.51 (1.00, 2.00)
T_1/2 (h)	2.16 ± 0.34	2.27 ± 0.29	2.06 ± 0.37
SFN-NAC
AUC_0-inf (h*ng/mL)	443.5 ± 136.9	448.9 ± 198.3	439.8 ± 85.6
C_max (ng/mL)	75.1 ± 16.5	67.1 (59.8, 86.8)	73.3 (65.8, 85.0)
T_max (h)	3.20 ± 1.01	3.99 (2.00, 4.00)	4.00 (2.00, 4.00)
T_1/2 (h)	2.59 ± 0.66	2.59 (2.26, 3.19)	2.46 (2.04, 2.71)
SFN-GSH
AUC_0-inf (h*ng/mL)	475.1 ± 224.2	555.5 ± 274.3	421.5 ± 176.3
C_max (ng/mL)	160.9 ± 73.0	197.6 ± 78.8	136.5 ± 60.3
T_max (h)	1.35 ± 0.79	1.02 (0.875, 2.00)	1.00 (1.00, 1.51)
T_1/2 (h)	2.07 ± 0.57	1.86 (1.719, 2.400)	1.82 (1.74, 2.31)

^#

Significantly different from Null/Null; p<0.05