Table 3.
Univariate analysis of likelihood of pCR on Yale Neoadjuvant Cohort
| Univariate |
|||
|---|---|---|---|
| Variable | Odds Ratio* |
95% CI | P-value |
| Age (y) | |||
| <50 | 1 | ||
| ≥50 | 0.923 | 0.377-2.259 | 0.8609 |
| Nodal Status | |||
| Positive | 0.126 | 0.042-0.379 | 0.0002 |
| Negative | 1 | ||
| Tumor Size (cm) | |||
| <2 | 1 | ||
| >2 | 0.383 | 0.101-1.449 | 0.1575 |
| Nuclear Grade | |||
| 1-2 | 1 | ||
| 3 | 2.485 | 0.983-6.278 | 0.0543 |
| ER | |||
| Negative | 1 | ||
| Positive | 0.488 | 0.197-1.209 | 0.1211 |
| PR | |||
| Negative | 1 | ||
| Positive | 0.415 | 0.167-1.030 | 0.0579 |
| HER2 | |||
| Negative | 1 | ||
| Positive | 2.357 | 0.901-6.167 | 0.0806 |
| Triple Negative | |||
| No | 1 | ||
| Yes | 2.222 | 0.831-5.941 | 0.1115 |
| LPBC | |||
| No | 1 | ||
| Yes | 4.697 | 1.036-21.302 | 0.0449 |
| Epithelial PD-L1 | |||
| Low | 1 | ||
| High | 2.667 | 0.945-7.528 | 0.0639 |
| Stromal PD-L1 | |||
| Low | 1 | ||
| High | 2.804 | 0.982-8.006 | 0.0541 |
*
Odds Ratio indicates likelihood of pCR